Role of Circulating DNA in the Precocious Diagnosis of Lymphoma: an example in a Transplant-Related Aggressive Lymphoma
| Autor: | Enrico Orciuolo, Susanna Grassi, Federico Rossari, Edoardo Benedetti, Cristina Zucchinetti, Elena Ciabatti, Eugenio Ciancia, Gabriele Buda, Ugo Boggi, Mario Petrini, Francesca Guerrini, Luca Biavati, Maria Immacolata Ferreri, Sara Galimberti, Francesco Caracciolo |
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| Rok vydání: | 2019 |
| Předmět: |
0209 industrial biotechnology
Pathology medicine.medical_specialty 021103 operations research business.industry 0211 other engineering and technologies Aggressive lymphoma Karyotype 02 engineering and technology Disease medicine.disease Circulating Cell-Free DNA Lymphoma 020901 industrial engineering & automation medicine.anatomical_structure immune system diseases hemic and lymphatic diseases medicine Bone marrow Clone (B-cell biology) business B-cell lymphoma |
| Popis: | We report the case of an aggressive non-Hodgkin lymphoma transmission from a live renal donor to her recipient. Soon after donation, the donor developed a high-grade B cell lymphoma, and the disease became evident also in the recipient three months thereafter, showing the same biological characteristics as confirmed by IgH rearrangement, karyotype and chimerism analyses. In the recipient, the IgH clone appeared in circulating cell free DNA (cfDNA), but not in peripheral blood nor in bone marrow, one month earlier than the imaging evidence of disease. This case supports the fundamental predictive role of molecular analysis of the plasma compartment in the diagnosis and putatively follow up of lymphomas |
| Databáze: | OpenAIRE |
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