Influence of Amorphous Fraction from Adrenal Cortex on Efficiency of Muscle
| Autor: | Edward C. Kendall, Dwight J. Ingle |
|---|---|
| Rok vydání: | 1940 |
| Předmět: |
medicine.medical_specialty
Chemistry Adrenal cortex medicine.medical_treatment chemistry.chemical_element Carbohydrate metabolism medicine.disease Oxygen General Biochemistry Genetics and Molecular Biology Steroid Amorphous solid medicine.anatomical_structure Endocrinology Atrophy Epinephrine Internal medicine Cortex (anatomy) medicine medicine.drug |
| Zdroj: | Experimental Biology and Medicine. 45:602-606 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-45-11766 |
| Popis: | An extract of the atlrenal cortex which is free from epinephrine and contains the physiologically active steroid derivatives characteristic of the adrenal cortex can he separated into a surprisillgly large number of crystalline compounds and an amorphous fraction. The crystalline compounds A, B, E, and F, which have an atom of oxygen attached to C11, have a nlarked effect on the efficiency of muscle1 and on carbhidrate metabolism23, hut relatively large amotmts are recluired to maintain renal function. When large amounts are administered to normal male rats these compounds produce atrophy of the adreiial and thymus glands.4,5 Desoxycorticosterone, which is identical with compound B except that there is no atom of oxygen on C11, has hut little effect on the efficiency of muscle and on carbohydrate metabolism, hut it is from 6 to 10 times more efficient than compound E when renal function is used as a criterion. The amorphous fraction has the greatest effect on renal function aid it protects the adrenalecto... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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