Cadmium and Its Health Effects. Low Dose Exposure to Cadmium and Its Health Effects. (1). Genotoxicity and Carcinogenicity

Autor:	Hiroshi Koyama, Masahiko Satoh, Chiharu Tohyama, Hideaki Kitoh
Rok vydání:	2002
Předmět:	business.industry DNA damage General Medicine Environmental exposure medicine.disease_cause medicine.disease Prostate cancer medicine.anatomical_structure Prostate Cancer research Medicine business Carcinogenesis Lung cancer Genotoxicity Carcinogen
Zdroj:	Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene). 57:547-555
ISSN:	1882-6482 0021-5082
DOI:	10.1265/jjh.57.547
Popis:	We reviewed studies on genotoxicity and carcinogenicity of cadmium (Cd). Salmonella typhimurium and Escherichia coli exposed to Cd did not show mutagenicity, whereas cultured mammalian cells exposed to Cd showed mutation, DNA strand breaks, and chromosomal aberrations. Carcinogenicity tests showed that exposure to Cd increased the occurrence of tumors in testis, lung, prostate, hematopoietic tissues, and injection sites. On the other hand, recent epidemiologic studies are not supportive of earlier observations on the association between Cd and prostate cancer. The US NIOSH data on a possible association between Cd and lung cancer may need reevaluation. No studies which show a positive relationship between oral Cd exposure and carcinogenesis have been reported. All available data suggest that Cd should be reassigned to IARC Group 2A (probably carcinogenic to humans) from the current Group 1.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9f7cb0c0b3e674d76a464b5e4c530025 https://doi.org/10.1265/jjh.57.547 Zobrazit plný text záznamu