Novel glucocorticoid antedrugs possessing a 21-(γ-lactone) ring

Autor:	Panayiotis A. Procopiou, Sean M. Lynn, Ashley Paul Hancock, Rosanne Mary Farrell, Stephen Sean Flack, Wendy R. Irving, Keith Biggadike, Richard Martyn Angell
Rok vydání:	2002
Předmět:	chemistry.chemical_classification biology Lability Stereochemistry Pregnane Paraoxonase Ring (chemistry) Hydrolysis chemistry.chemical_compound Enzyme chemistry biology.protein medicine Glucocorticoid Lactone medicine.drug
Zdroj:	Journal of the Chemical Society, Perkin Transactions 1. :831-839
ISSN:	1364-5463 1472-7781
DOI:	10.1039/b200190j
Popis:	A series of novel pregnane derivatives bearing γ-butyrolactones at C21 were prepared and tested as glucocorticoid agonists. The compounds were also tested for their lability in human plasma, and found to be rapidly hydrolysed by the enzyme paraoxonase to the respective hydroxyacids.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9f4f7e24ca42601a28ea7baaa04f240a https://doi.org/10.1039/b200190j Zobrazit plný text záznamu