Intravenous immunoglobulin as an adjunct to plasma exchange for the treatment of chronic thrombotic thrombocytopenic purpura
| Autor: | Jane C. Moore, Donald M. Arnold, John G. Kelton, Brian Leber, Rumi Clare, G. J. Molnar |
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| Rok vydání: | 2007 |
| Předmět: |
Thrombospondin
Metalloproteinase biology business.industry medicine.medical_treatment Thrombotic thrombocytopenic purpura Hematology General Medicine Disease respiratory system medicine.disease ADAMTS13 hemic and lymphatic diseases Immunology medicine biology.protein heterocyclic compounds Therapeutic plasma exchange Antibody business neoplasms therapeutics Adjuvant |
| Zdroj: | Vox Sanguinis. 93:173-175 |
| ISSN: | 0042-9007 |
| DOI: | 10.1111/j.1423-0410.2007.00939.x |
| Popis: | Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disease. Therapeutic plasma exchange (TPE) is the most effective therapy; however, despite TPE, about one-third of TTP patients will relapse. A subset of patients with TTP has antibodies to ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) and may become resistant to conventional treatments. We describe a patient with TTP and high-titre anti-ADAMTS13 antibodies who developed a chronic, relapsing course of TTP despite frequent TPE. Once adjuvant treatment with intravenous immunoglobulin (IVIG) was added, remission was achieved. Even during remission, anti-ADAMTS13 antibodies remained elevated. We conclude that IVIG may sustain remission in some patients with chronic, relapsing TTP. |
| Databáze: | OpenAIRE |
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