Levels of soluble ICAM-1 and soluble IL-2R in the serum and aqueous humor of uveitis patients
| Autor: | Manuel Santos Lacomba, Carlos Ignacio Serrano Molina, Carmen Martín, Eduardo Collantes Estevez, Jose Maria Gallardo Galera, Rafael Ramírez Chamond |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
chemistry.chemical_classification
ICAM-1 genetic structures business.industry Aqueous humor Pharmacology medicine.disease eye diseases Sensory Systems Peripheral blood Cellular and Molecular Neuroscience Ophthalmology Enzyme chemistry Immunology medicine In patient sense organs business Receptor Uveitis Immune activation |
| Zdroj: | Current Eye Research. 20:287-292 |
| ISSN: | 1460-2202 0271-3683 |
| DOI: | 10.1076/0271-3683(200004)2041-5ft287 |
| Popis: | Purpose. To study the ocular and systemic behaviour of the immune activation markers soluble ICAM-1 and soluble IL-2R in patients with active uveitis. Methods. We determined the levels of soluble ICAM-1 and soluble IL-2R in the aqueous humor and peripheral blood of 23 patients with active uveitis and 16 age and gender matched controls (who were to undergo cataract extraction) by means of ELISA enzyme immunoanalysis. Results. Patients with uveitis presented higher levels of soluble ICAM-1 and soluble IL-2R in the aqueous humor and peripheral blood. Comparison of the aqueous humor and peripheral blood revealed higher levels of soluble ICAM-1 in the aqueous humor, while we found no differences for soluble IL-2R. Analysis of the clinical characteristics of the uveitis we studied showed no differences in the levels of these markers in either blood or aqueous humor. Conclusions. The finding of elevated levels of soluble IL-2R and soluble ICAM-1 in the aqueous humor and peripheral blood of patients with uveitis ... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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