| Autor: |
Mohammad Abdallah Shazly, Mohammed Osman Azzazi, Mohamed Samra, Ahmed Youssri Elsaed |
| Rok vydání: |
2022 |
| DOI: |
10.21203/rs.3.rs-2108381/v1 |
| Popis: |
Background: Chronic myeloid leukemia (CML) is one of malignant hematologic disorders arises from hematopoietic stem cells. BCR-ABL transcript levels on the international scale at 3 and 6 months are defined as indicators of the early efficacy of first line TKI treatment. Aim To investigate the impact of early molecular response (EMR; BCR-ABL ≤ 10% on the International scale at 3 or 6 months) on outcome of the newly diagnosed CML in chronic phase treated with Nilotinib. Patients and Methods: The study was enrolled from 2018 to 2020 at Nasser Institute for Research and Treatment.This is a prospective cohort study done on 94 newly diagnosed CML cases in Chronic Phase. Results: A statistically significant difference was detected between patients not achieved EMR with peripheral blasts ≥5%, when compared to others achieved EMR with peripheral blasts 75% of patients not achieved EMR were ≥55 years age at diagnosis; and 90% of patients achieved EMR were 25% of cases not achieved EMR were compliant, while other cases achieved EMR were compliant with (PConclusion: EMR is an important prognostic significance for CML patients received treatment with Nilotinib. Patients who achieved EMR had significantly better outcome. Achieving MR3.0 should be the aim in patents with CML-CP who have a 3-month BCR-ABL ≤ 10% and 6-month BCR-ABL ≤ 10%. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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