Suppression of tumor cell growth by allospecific cytotoxic T-lymphocytes in vitro
| Autor: | L. M. Khromykh, D. B. Kazanskii, T. V. Anfalova |
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| Rok vydání: | 2007 |
| Předmět: |
Mutation
General Immunology and Microbiology Effector Cell growth Chemistry hemic and immune systems chemical and pharmacologic phenomena General Medicine medicine.disease_cause General Biochemistry Genetics and Molecular Biology In vitro CTL Immune system Immunology medicine Cancer research Cytotoxic T cell General Agricultural and Biological Sciences Homeostasis |
| Zdroj: | Doklady Biological Sciences. 413:172-175 |
| ISSN: | 1608-3105 0012-4966 |
| DOI: | 10.1134/s0012496607020251 |
| Popis: | 172 Cytotoxic T-lymphocytes (CTLs) are the main cytotoxic effector cells of the immune system. Cytotoxic Tlymphocytes are able to control homeostasis by recognizing and eliminating the cells that were infected or underwent mutation or malignization. The results of our previous study of allospecific CTL lines (allo-CTL) demonstrated new regulatory functions of these cells. It was found that, despite the fact that allo-CTL lines exhibited strict specificity in killer activity tests, they drastically inhibited proliferation of activated lymphocytes of various haplotypes, including the syngeneic ones, irrespective of the specificity of CTLs. In particular, CTLs completely inhibited proliferation induced during response development in a mixed lymphocyte culture (MLC). A similar effect was observed when CTLs were added to mitogen-activated T-lymphocytes. However, CTLs almost had no effect on cell proliferation intensity in the syngeneic MLC and on spontaneous proliferation of nonactivated cells [1]. |
| Databáze: | OpenAIRE |
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