| Popis: |
Background: Recently, the relationship between obesity and breast cancer has been clarified, and findings obtained in a study that used body mass index (BMI) suggested that its presence might increase the risk for development of that disease. However, the association between metabolic syndrome caused by obesity and development of mammary gland disease has not been elucidated in a longitudinal manner. In the present case-control study, that association was examined.Methods: Two hundred sixty-five women who underwent breast cancer screening with mammography and measurements of metabolic syndrome factors, including waist circumference, blood glucose, and triglycerides, HDL-cholesterol levels, and systolic and diastolic blood pressure, twice within a 2-year period at the Disease Prevention Promotion and Research Center of the Dai-ikai Medical Corporation were enrolled. To determine the presence of mammary gland disease, 2 expert physicians interpreted radiogram findings, with category 3 or higher shown by mammography considered to indicate an abnormality.Results and Discussion: Waist circumference at the initial measurement was shown to be significantly associated (odds ratio=1.036, p=0.045) as a risk factor for onset of mammary gland disease. During the 2-year examination period, changes in systolic blood pressure (odds ratio=1.020, p=0.085) and diastolic pressure (odds ratio=1.040, p=0.065) showed a marginally significant association. As for protective factors, HDL-cholesterol level (odds ratio=0.982, p=0.064) at the initial examination was confirmed to have a marginally significant relationship. We concluded that waist circumference and 2-year changes in systolic and diastolic blood pressure are risk factors for mammary gland disease, while HDL-cholesterol level is a protective factor. |
