Lectinomics I. Relevance of exogenous plant lectins in biomedical diagnostics
| Autor: | Anna Kozarova, Peter Gemeiner, Tibor Kožár, Danica Mislovičová |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Medical diagnostic
Glycosylation Lectin Cell Biology Plant Science Computational biology Biology Plant Lectins Bioinformatics Diagnostic tools Biochemistry Clinical microbiology chemistry.chemical_compound chemistry Genetics biology.protein Animal Science and Zoology Relevance (information retrieval) Identification (biology) Molecular Biology Ecology Evolution Behavior and Systematics |
| Zdroj: | Biologia. 64:1-19 |
| ISSN: | 1336-9563 0006-3088 |
| Popis: | This review focuses on utilization of plant lectins as medical diagnostic reagents and tools. The lectin-related diagnostic is aimed at detection of several diseases connected to alteration of the glycosylation profiles of cells and at identification of microbial and viral agents in clinical microbiology. Certain lectins, proposed for or used as diagnostic tools could even recognize those cellular determinants, which are not detected by available antibodies. Broad information is presented on the lectinomics field, illustrating that lectin diagnostics might become practical alternative to antibody-based diagnostic products. In addition, the rising trend of lectin utilization in biomedical diagnostics might initiate a development of innovative methods based on better analytical technologies. Lectin microarray, a rapid and simple methodology, can be viewed as an example for such initiative. This technology could provide simple and efficient screening tools for analysis of glycosylation patterns in biological samples (cellular extracts, tissues and the whole cells), allowing thus personalized detection of changes associated with carbohydrate-related diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink