Enantioselective Synthesis of (+)-Aphanorphine by Means of SamariumDiiodide Promoted Reductive Carbon-Nitrogen Bond-Cleavage Reaction

Autor:	Miho Katoh, Atsuko Suzuki, Toshio Honda, Hiroshi Inoue
Rok vydání:	2005
Předmět:	chemistry.chemical_compound chemistry Samarium diiodide Stereochemistry Carbon–nitrogen bond Organic Chemistry Enantioselective synthesis Aphanorphine Cleavage (embryo) Medicinal chemistry Derivative (chemistry)
Zdroj:	Synlett. :2820-2822
ISSN:	1437-2096 0936-5214
Popis:	An enantioselective synthesis of (+)-aphanorphine has been achieved by application of a samarium diiodide promoted reductive carbon-nitrogen bond-cleavage reaction to a 1-methoxycarbonyl-1,2,3,4-tetrahydroisoquinoline providing a benzazepinone derivative as a key step.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9e38791c9c501cd73a73844606e56470 https://doi.org/10.1055/s-2005-918925 Zobrazit plný text záznamu