A study of the anti-plasmodium activity of angiotensin II analogs
| Autor: | Erick Leite Bastos, Adriana F. Silva, Vani Xavier Oliveira, Mayra Chamlian, Antonio Miranda, Marcelo D. T. Torres, Margareth Lara Capurro, Ceres Maciel |
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| Rok vydání: | 2013 |
| Předmět: |
Pharmacology
chemistry.chemical_classification Organic Chemistry Peptide General Medicine Biology biology.organism_classification Biochemistry Angiotensin II In vitro Amino acid Plasmodium gallinaceum Residue (chemistry) chemistry.chemical_compound chemistry Structural Biology parasitic diseases Drug Discovery Renin–angiotensin system Lactam Molecular Medicine Molecular Biology |
| Zdroj: | Journal of Peptide Science. 19:575-580 |
| ISSN: | 1075-2617 |
| Popis: | Controlling the dissemination of malaria requires the development of new drugs against its etiological agent, a protozoan ofthe Plasmodium genus. Angiotensin II and its analog peptides exhibit activity against the development of immature andmature sporozoites of Plasmodium gallinaceum. In this study, we report the synthesis and characterization of angiotensin IIlinear and cyclic analogs with anti-plasmodium activity. The peptides were synthesized by a conventional solid-phase methodon Merrifield's resin using the t-Boc strategy, purified by RP-HPLC and characterized by liquid chromatography/ESI (+) MS(LC-ESI(+)/MS), amino acid analysis, and capillary electrophoresis. Anti-plasmodium activity was measured in vitro byfluorescence microscopy using propidium iodine uptake as an indicator of cellular damage. The activities of the linear andcyclic peptides are not significantly different (p |
| Databáze: | OpenAIRE |
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