A Case of Dichorionic Twin Pregnancy with Maternal Propylthiouracil Induced Hypothyroid Goiter in Both Fetuses Treated with Intramniotic Levothyroxine
| Autor: | P. S. Sreeja, Swapneel Neelkanth Patil, Gopinathan Kannoly, Seneesh Kumar Vikraman, Meenu Batra, Bijoy Balakrishnan |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
endocrine system
medicine.medical_specialty Pregnancy Amniotic fluid endocrine system diseases business.industry Obstetrics Thyroid Levothyroxine 030209 endocrinology & metabolism medicine.disease 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Endocrinology 030225 pediatrics Modeling and Simulation Internal medicine medicine Gestation Euthyroid Propylthiouracil business Twin Pregnancy medicine.drug |
| Zdroj: | Journal of Fetal Medicine. :45-48 |
| ISSN: | 2348-8859 2348-1153 |
| DOI: | 10.1007/s40556-017-0139-x |
| Popis: | Fetal hypothyroid goiters are observed in 1:40,000 births. They are usually attributed to underlying thyroid glandular dysgenesis, dyshormonogenesis, or an adverse effect of maternal anti-thyroid drugs. The objective of the present case report is to outline the details of a twin gestation with hypothyroid goiter in both fetuses managed by intramniotic levothyroxine administration. The index pregnancy was of dichorionic twin gestation in which the mother was receiving oral propylthiouracil. Fetal goiters were first detected in ultrasound performed at 31 weeks of gestation. The hypothyroid nature of goiters was confirmed by cordocentesis from both sacs. Intramniotic administration of 100 μg of levothyroxine into both sacs was performed twice at the interval of two weeks. The response to treatment was assessed by amniotic fluid thyroid hormone levels, and serial measurement of thyroid gland volume. Emergency cesarean section was performed at 35 weeks due to preterm labor. Both fetuses were euthyroid at birth and were discharged in good health. |
| Databáze: | OpenAIRE |
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