Counter-current immunoelectrophoresis for the diagnosis of pneumococcal chest infection
| Autor: | C. Dulake |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty medicine.diagnostic_test business.industry medicine.drug_class Antibiotics Immunoelectrophoresis medicine.disease Counter-current immunoelectrophoresis Pneumonia Infectious Diseases Internal medicine Antibiotic therapy Capsular antigen Immunology medicine Sputum medicine.symptom business |
| Zdroj: | Journal of Infection. 1:45-51 |
| ISSN: | 0163-4453 |
| DOI: | 10.1016/s0163-4453(79)80031-6 |
| Popis: | Summary Counter-current immunoelectrophoresis (CIE) for the detection of pneumococcal capsular antigen (PCA) in the sputum of patients with suspected chest infection increased the detection-rate of pneumococcal infection from nine per cent to 28 per cent overall. PCA was present in 72 per cent of cases of radiologically confirmed pneumonia, compared with a pneumococcal isolation-rate of 12 per cent in culture. The discrepancy is probably explained by previous antibiotic therapy. In post-operative chest infection where the sputum contained pus cells, pneumococci were isolated from 22 per cent of those not on antibiotics and from only eight per cent of those on therapy, whereas PCA was detected in 54 and 56 per cent of cases, respectively. PCA was detected in the serum of 14 patients with pneumonia, whereas blood cultures were positive in only four of these cases. Of these 14 patients, five died. In a further 30 patients with pneumonia in whom PCA was detected in the sputum, but not in the serum, there were only three deaths. |
| Databáze: | OpenAIRE |
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