Effect of piracetam on sensitivity to pain, blood?-endorphin level, and cerebral corticalcAMP level in rats

Autor:	O. P. Vakulina, V. V. Yasnetsov, V. A. Isachenko, I. N. Krylova, I. P. Tishkova, E. O. Bragin, E. V. Popkova
Rok vydání:	1990
Předmět:	Extracellular matrix Catabolism Chemistry In vivo Anesthesia Extracellular Cathepsin D General Medicine Portal tracts Ultrastructural cytochemistry General Biochemistry Genetics and Molecular Biology Intracellular Cell biology
Zdroj:	Bulletin of Experimental Biology and Medicine. 109:200-203
ISSN:	1573-8221 0007-4888
DOI:	10.1007/bf00841671
Popis:	Cathepsin D localization was studied in the liver of white rats by ultrastructural cytochemistry. It was shown that the product of reaction was present in lysosomes of hepatocytes, Kupffer's and endothelial cells and in fibroblasts from portal tracts am small granules or their conglomerate of different electron density. The lowest activity of cathepsin D was observed in hepatocytes, the most intensive reaction--in Kupffer cells. The extracellular activity of cathepsin D in vivo was revealed. It means that besides participation in intracellular degradation of different proteins, cathepsin D is secreted to extracellular space by liver cells (hepatocytes, Kupffer cells, fibroblasts) and it may participate in catabolism of intercellular matrix.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9d9c3401e38692888e5197e5b3171d2b https://doi.org/10.1007/bf00841671 Zobrazit plný text záznamu Full text from SpringerLink