Converting cell fates: generating hematopoietic stem cellsde novovia transcription factor reprogramming
| Autor: | Ihor R. Lemischka, Michael G. Daniel, Kateri A. Moore |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Genetics Induced stem cells General Neuroscience medicine.medical_treatment Cellular differentiation Stem-cell therapy Biology Embryonic stem cell General Biochemistry Genetics and Molecular Biology Cell biology 03 medical and health sciences 030104 developmental biology History and Philosophy of Science medicine Stem cell Induced pluripotent stem cell Cell potency Reprogramming |
| Zdroj: | Annals of the New York Academy of Sciences. 1370:24-35 |
| ISSN: | 0077-8923 |
| DOI: | 10.1111/nyas.12989 |
| Popis: | Even though all paradigms of stem cell therapy and regenerative medicine emerged from the study of hematopoietic stem cells (HSCs), the inability to generate these cells de novo or expand them in vitro persists. Initial efforts to obtain these cells began with the use of embryonic stem cell (ESC) and induced pluripotent stem cell (iPSC) technologies, but these strategies have yet to yield fully functional cells. Subsequently, more recent approaches involve transcription factor (TF) overexpression to reprogram PSCs and various somatic cells. The induction of pluripotency with just four TFs by Yamanaka informs our ability to convert cell fates and demonstrates the feasibility of utilizing terminally differentiated cells to generate cells with multilineage potential. In this review, we discuss the recent efforts undertaken using TF-based reprogramming strategies to convert several cell types into HSCs. |
| Databáze: | OpenAIRE |
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