GONADOTROPIC HORMONE: CLINICAL APPLICATION OF EXTRACTION METHODS FOR ASSAY PURPOSES1

Autor:	Carl G. Heller, Emily J. Heller
Rok vydání:	1939
Předmět:	medicine.medical_specialty Gonadotropic hormones medicine.drug_class Urine Biology Endocrinology Extant taxon Internal medicine Rat uterus medicine Extraction methods Gonadotropin Hormone
Zdroj:	Endocrinology. 24:319-325
ISSN:	1945-7170 0013-7227
DOI:	10.1210/endo-24-3-319
Popis:	THE TWO MAIN obstacles which must be overcome to make possible an accurate assay of non-pregnancy urinary gonadotropic hormones are: a), a reliable assay end-point, and b), a satisfactory concentration method. The first obstacle has been satisfactorily removed (I) with the thorough investigation of the immature rat uterus and ovary as end-points for the assay of gonadotropic hormones. Overcoming the second is of primary concern at this time. The reports of efforts in this direction are legion, indicating the general dissatisfaction with the concentration methods now extant. For the routine assay of large numbers of urine specimens from many different patients, any urine concentration method must meet the following prerequisites: a), It must be simple, in order that large quantities of individual specimens may be handled, b), It must concentrate the active fraction many times; because of the low content of some urines, the gonadotropic activity of from 500 cc.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9d4de2d4fc972cac7cbffc6e3e2051f0 https://doi.org/10.1210/endo-24-3-319 Zobrazit plný text záznamu