High flow nasal cannula during walking in severe COPD patients: a randomized controlled trial
| Autor: | Serena Cirio, Veronica Rossi, Annalisa Carlucci, Piero Ceriana, Giuditta Bettinelli, Manuela Piran, Laura Zocchi |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Exercise limitation
COPD business.industry Severe copd medicine.disease_cause medicine.disease law.invention 03 medical and health sciences 0302 clinical medicine 030228 respiratory system Randomized controlled trial Walk test law Anesthesia medicine 030212 general & internal medicine High flow Dynamic hyperinflation business human activities Nasal cannula |
| Zdroj: | Rehabilitation and Chronic Care. |
| DOI: | 10.1183/13993003.congress-2018.pa3645 |
| Popis: | Exercise tolerance may be significantly impaired in severe COPD. NIV increases the walking distance; however a 35% of patients do not tolerate it (Walker DJ et al. COPD 2015;1:546-51). Recently, it has been demonstrated that high flow nasal cannula (HFNC) improves the endurance time in severe COPD patients (Cirio S et al. Respir Med. 2016 Sep;118:128-132). However, the lack of an internal battery has limited its use for moving. Our study aimed to investigate if HFNC powered by an external battery increases the walking distance in COPD patients with exercise limitation. Thirteen stable COPD patients with a walking distance lower than 70% of predicted value associated to a modified Borg dyspnea SB ≥5 at 6-minute walk test (6MWT), were included. They performed two consecutive 6MWTs, in a randomised cross-over design: with and without HFNC at the same oxygen inhaled fraction. Twelve patients (one dropped-out) (mean ±SD age 69.5 ±10.3 yrs, forced expiratory volume in 1 second 25±5.6% predicted) were analysed. Walking distance was significantly higher using HFNC (median 306m (IQR 246-342) compare to no-HFNC (267m (IQR 228-294) (p In conclusion, HFNC may be safely used also during walking. In severe COPD with exercise limitation it improves the walking distance without worsening of dynamic hyperinflation. |
| Databáze: | OpenAIRE |
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