Fe3O4-alginate nanocomposite hydrogel beads material: One-pot preparation, release kinetics and antibacterial activity
| Autor: | Djelad Amal, Abdelkrim Soumia, Sardi Amina, Bengueddach Abdelkader, Boukoussa Bouhadjar, Zaoui Farouk, Mokhtar Adel, Sassi Mohamed |
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| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
Denticity Nanocomposite Chemistry Kinetics 02 engineering and technology General Medicine engineering.material 021001 nanoscience & nanotechnology Biochemistry 03 medical and health sciences Structural Biology Drug delivery engineering High activity Biopolymer 0210 nano-technology Antibacterial activity Molecular Biology 030304 developmental biology Sodium alginate Nuclear chemistry |
| Zdroj: | International Journal of Biological Macromolecules. 145:466-475 |
| ISSN: | 0141-8130 |
| Popis: | In this work, a new and easy process was developed to fabricate a Fe3O4-alginate (Fe3O4NPs-ALG) hydrogel nanocomposite magnetic beads material. This preparation way consists in crosslinking sodium alginate solution in a mixed iron chloride solution containing FeCl3 and FeCl2. All characterization techniques confirmed the formation of small Fe3O4 nanoparticles with an average size of 9 nm in the alginate biopolymer matrix, in which iron atoms were linked to carbonyl acetyl groups through a bidentate bridging coordination. Furthermore, the magnetic nanocomposite beads have negatively charged surface. The obtained material was loaded with amoxicillin (AMOX) and tested as drug delivery system in the biolysis serum (NaCl 0.9% of pH 7) and in the simulated gastric medium (pH 2.1). The results showed that a cumulative release rate of 81.49% was obtained after three days in the biolysis serum, while this release rate was about 11.65% only, after four days, in the simulated gastric medium. The kinetic release data fulfilled Korsmeyer-Peppas model and the Hixson-Crowell, respectively. Antibacterial test on drug-loaded nanocomposite beads showed high activity against three of pathogenic bacteria strains. |
| Databáze: | OpenAIRE |
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