Virulence-attenuated Salmonella engineered to secrete immunomodulators reduce tumour growth and increase survival in an autochthonous mouse model of breast cancer
| Autor: | Sara E. Hastings, Daniel A. Saltzman, Arnold S. Leonard, Liming Milbauer, Janet L. Schottel, Lance B. Augustin |
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| Rok vydání: | 2020 |
| Předmět: |
Salmonella
business.industry medicine.medical_treatment Pharmaceutical Science Virulence 02 engineering and technology 021001 nanoscience & nanotechnology medicine.disease_cause medicine.disease Colonisation 03 medical and health sciences 0302 clinical medicine Breast cancer Cancer immunotherapy Interleukin 15 030220 oncology & carcinogenesis Toxicity medicine Cancer research Secretion 0210 nano-technology business |
| Zdroj: | Journal of Drug Targeting. 29:430-438 |
| ISSN: | 1029-2330 1061-186X |
| DOI: | 10.1080/1061186x.2020.1850739 |
| Popis: | The ultimate goal of bacterial based cancer therapy is to achieve non-toxic penetration and colonisation of the tumour microenvironment. To overcome this efficacy-limiting toxicity of anticancer im... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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