Spontaneous intestinal perforation and multiple thrombotic events in a neonate with thrombophilia

Autor:	Philippe Trougouboff, Dan Reich, Carina Levin, Clari Felszer, Marina Peniakov, Ariel Koren
Rok vydání:	2014
Předmět:	Embryology medicine.medical_specialty business.industry Pediatrics Perinatology and Child Health medicine Factor V Leiden Spontaneous Intestinal Perforation Obstetrics and Gynecology Thrombophilia medicine.disease business Thrombosis Surgery
Zdroj:	Case Reports in Perinatal Medicine. 3:155-157
ISSN:	2192-8959 2192-8932
DOI:	10.1515/crpm-2013-0081
Popis:	Spontaneous intestinal perforation (SIP), a rare complication in neonates, was diagnosed in a preterm newborn. After surgery, small bowel histology showed acute ischemic changes and one area of perforation. Fibrin thrombus in the submucosal capillary vessels suggested a thrombotic mechanism in the pathogenesis. Subsequently, two severe asynchronous thrombotic events developed: cerebral sinovenous thrombosis and renal vein and inferior vena cava thrombosis. The neonate presented with hypercoagulability and factor V Leiden heterozygosity. This is the first association of SIP with inherited thrombophilia and thrombotic events in a neonate, suggesting hypercoagulability as a new research focus for pathogenesis of this enigmatic disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9cd401938928a9d84139c3791a7192d2 https://doi.org/10.1515/crpm-2013-0081 Zobrazit plný text záznamu