Single-Limb Irradiation Induces Local and Systemic Bone Loss in a Murine Model

Autor:	Ning Ma, Laura E. Coats, Anne M. Scheidler, Sutha John, Ted A. Bateman, Khalid S. Mohammad, Teresita Bellido, Sreemala Murthy, Helen Chin-Sinex, Hun Soo Kim, Marc S. Mendonca, Yun She, Jeroen T. Buijs, Theresa A. Guise, Laura E. Wright
Rok vydání:	2015
Předmět:	Pathology medicine.medical_specialty business.industry Osteoid Endocrinology Diabetes and Metabolism Osteoblast Bone healing medicine.anatomical_structure Osteoclast Osteocyte medicine Orthopedics and Sports Medicine Femur MC3T3 Bone marrow business
Zdroj:	Journal of Bone and Mineral Research. 30:1268-1279
ISSN:	0884-0431
DOI:	10.1002/jbmr.2458
Popis:	Increased fracture risk is commonly reported in cancer patients receiving radiotherapy, particularly at sites within the field of treatment. The direct and systemic effects of ionizing radiation on bone at a therapeutic dose are not well-characterized in clinically relevant animal models. Using 20-week-old male C57Bl/6 mice, effects of irradiation (right hindlimb; 2 Gy) on bone volume and microarchitecture were evaluated prospectively by microcomputed tomography and histomorphometry and compared to contralateral-shielded bone (left hindlimb) and non-irradiated control bone. One week postirradiation, trabecular bone volume declined in irradiated tibias (–22%; p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9c33016c9bfc0461b2949cfaa72274c1 https://doi.org/10.1002/jbmr.2458 Zobrazit plný text záznamu Plný text