Interleukin-2 (IL-2) production and interleukin-2 receptor expression in patients with aplastic anemia

Autor:	Zhao Zhiping, Lian Tianshun
Rok vydání:	1991
Předmět:	Interleukin 2 Cancer Research biology business.industry Receptor expression Bone marrow failure Lectin Stimulation medicine.disease Peripheral blood mononuclear cell Oncology Immunology biology.protein Medicine Aplastic anemia business Receptor medicine.drug
Zdroj:	Chinese Journal of Cancer Research. 3:70-73
ISSN:	1993-0631 1000-9604
Popis:	IL-2 production and IL-2 receptor (Tac antigen) of the peripheral blood mononuclear cells in 30 patients with aplastic anemic (AA) were studied. We found that mononuclear cells from patients produce spontaneously IL-2 in the absence of exogenous lectin stimulation, the proportion of Tac+ cells in mononuclear cells increased. The release of IL-2 and/or Tac antigen expression were elevated in almost every patient with AA. The plasma from patients stimulate mitogen-induced blastogenesis and Tac antigen expression of normal human lymphocytes. Immunological 1 abnormalities of patients with AA possibly might represents secondary response to bone marrow depression.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9be17a7ad1c80f73dfbf223f372912b6 https://doi.org/10.1007/bf02672096 Zobrazit plný text záznamu Full text from SpringerLink