Seven new Lycopodium alkaloids from the aerial parts of Phlegmariurus squarrosus
| Autor: | Edward J. Kennelly, Li Xu, Ping Li, Shi-Biao Wu, Wen Huang, Ze-E. Chen, Jingxian Zhuo, Zhiyong Guo, Li-Juan Ma, Chunlin Long, Wujisiguleng Cao |
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| Rok vydání: | 2015 |
| Předmět: |
Lycopodium
biology Lycopodiaceae Chemistry medicine.drug_class Stereochemistry Organic Chemistry biology.organism_classification Mass spectrometry Biochemistry Acetylcholinesterase chemistry.chemical_compound Phlegmariurus squarrosus Acetylcholinesterase inhibitor Drug Discovery medicine Organic chemistry Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Tetrahedron. 71:5308-5314 |
| ISSN: | 0040-4020 |
| DOI: | 10.1016/j.tet.2015.06.012 |
| Popis: | Seven new Lycopodium alkaloids, squarrosusines A-E (1-3, 5 and 6), 8-epilycoposerramine U (4) and squarrosusine F N-exide (7), and 4 related known compounds (8-11) were isolated from the aerial parts of Phlegmariurus squarrosus. The structures of these seven new compounds share a unique heterocyclic C16N-type skeleton. The chemical structures of the new compounds were established through spectroscopic methods, including 2D NMR techniques and mass spectrometry, as well as chemical reaction. The inhibition effects of the isolates against acetylcholinesterase (AChE) were evaluated in vitro. (C) 2015 Elsevier Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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