INFLUENCE OF ADAMANTANE 2-PYRROLIDONE DERIVATIVE ON PHYSICAL PERFORMANCE, PSYCHOEMOTIONAL AND COGNITIVE FUNCTIONS OF LABORATORY ANIMALS IN COMPARISON WITH BROMANTHANE
| Autor: | N. S Kovalev, D. A Bakulin, E. E Abrosimova, D. V Kurkin, V. E Pustynnikov, Yu. N Klimochkin, I. M Tkachenko, I. N Tyurenkov |
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| Rok vydání: | 2021 |
| Zdroj: | Journal of Volgograd State Medical University. 18:98-102 |
| ISSN: | 1994-9499 1994-9480 |
| DOI: | 10.19163/1994-9480-2021-2(78)-98-102 |
| Popis: | The effect of a new adamantane derivative of 2-pyrrolidone on the physical performance of rats when swimming with a load (for 5 days) was studied. It has been shown that a course, 5-day administration of IE-1 at a dose of 23 mg/kg 60 min before the first swim, significantly increases the swimming duration, comparable to that of bromantane. In addition, after a 5-day swim, animals treated with IE-1 showed higher motor and exploratory activity in the Open Field test, a lower level of anxiety in the Light/Dark Box test, and better indicators of cognitive function in the novel object recognition test. |
| Databáze: | OpenAIRE |
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