The Relationship of Systemic TNF-? and IFN-? with IVF Treatment Outcome and Peripheral Blood NK Cells
| Autor: | Hassan Shehata, Brian Ford, Hossam Abdalla, Emily L. Harden, Amolak S. Bansal, Meen-Yau Thum, Nazira Sumar, Shree Bhaskaran |
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| Rok vydání: | 2007 |
| Předmět: |
Infertility
medicine.medical_specialty Pregnancy business.industry medicine.medical_treatment Immunology Obstetrics and Gynecology medicine.disease Endocrinology Cytokine Reproductive Medicine Antigen Interferon Internal medicine medicine Immunology and Allergy Tumor necrosis factor alpha Live birth business Prospective cohort study medicine.drug |
| Zdroj: | American Journal of Reproductive Immunology. 57:210-217 |
| ISSN: | 1600-0897 1046-7408 |
| Popis: | Background To evaluate the association of serum tumour necrotic factor (TNF)-alpha and interferon (IFN)-gamma levels with IVF treatment outcome and peripheral blood NK cells. Methods Prospective observational study of 126 randomly selected women who underwent IVF treatment. The serum levels of TNF-alpha and IFN-gamma were determined by multiplex suspension beads array system. Results There were no significant differences with regard to the systemic TNF-alpha and IFN-gamma levels between the pregnant (n = 51, TNF-alpha: 53.5 pg/mL; IFN-gamma: 4.6 pg/mL) and not pregnant (n = 75, TNF-alpha: 63.0; IFN-gamma: 7.5) women after IVF treatment. For those women with a positive pregnancy after IVF treatment, the systemic TNF-alpha and IFN-gamma levels were higher in those women who miscarried (n = 13, TNF-alpha: 67.4; IFN-gamma: 9.1) when compared with those who had a live birth (n = 38, TNF-alpha: 48.7; IFN-gamma: 1.4), however this difference was not statistically significant. Interestingly, the systemic TNF-alpha and IFN-gamma levels were significantly higher in women who had a higher level of activated (CD69(+)) NK cells (n = 39, TNF-alpha: 86.8; IFN-gamma: 4.7) when compared with women who had a low level of activated NK cells (n = 87, TNF-alpha: 46.9; IFN-gamma: 1.7 P = 0.028 and 0.045 respectively). Conclusion The systemic levels of TNF-alpha and IFN-gamma have no association with implantation rate or miscarriage rate in women undergoing IVF treatment. However, high levels of TNF-alpha and IFN-gamma are associated with elevated levels of activated NK cells and this may subsequently exert a negative impact on reproduction. |
| Databáze: | OpenAIRE |
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