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Glioblastoma multiforme is the most common brain cancer in adults, and it offers a median overall survival of 15 months to those diagnosed with it (1, 2). The development of novel and targeted therapies to extend the survival of those diagnosed with glioblastoma requires a basic understanding of the transcriptional behavior of these tumors compared to the tissue from which it arises - the brain. In this study I compared the transcriptomes of 17 glioblastoma tumors to that of brain tissues from 8 non-affected individuals using a published dataset (3). I found that two genes encoding proteins involved in the cellular transport of endocytic vesicles, RAB11FIP2 and RAB11FIP4 were differentially expressed in the tumors of patients with glioblastoma. Both genes were expressed at significantly lower levels in glioblastoma tumors when compared to non-affected brain tissues. These molecules should be studied in greater depth to understand the cargoes that they transport and whether targeting of these molecules could represent a viable approach for the development of novel targeted therapeutics aimed at extending median survival in glioblastoma. |
