Discrepancy between serum leptin values and total body fat in response to the oral growth hormone secretagogue MK-677
| Autor: | John-Olov Jansson, Lena M. S. Carlsson, Björn Carlsson, Johan Svensson, B.-Å. Bengtsson |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
biology business.industry Endocrinology Diabetes and Metabolism Leptin Adipose tissue Placebo Follicle-stimulating hormone Endocrinology Sex hormone-binding globulin Growth hormone secretagogue Internal medicine medicine biology.protein business Luteinizing hormone Testosterone |
| Zdroj: | Clinical Endocrinology. 50:451-456 |
| ISSN: | 0300-0664 |
| DOI: | 10.1046/j.1365-2265.1999.00667.x |
| Popis: | OBJECTIVE Growth hormone (GH) treatment decreases total body fat while this effect has not yet been documented for the oral GH secretagogue MK-677. In the present study, the effects of MK-677 treatment on serum levels of leptin, thyroid hormones and testosterone were determined. DESIGN This was a randomized, double-blind, and parallel study. Twenty-four healthy obese males, 19–49 years of age, with body mass index (BMI) > 30 kg/m2 and a waist:hip ratio > 0.95, were treated with MK-677 (25 mg/day; n = 12) or placebo (n = 12) for 8 weeks. RESULTS MK-677 treatment increased serum leptin levels and leptin/body fat ratio at 2 weeks of treatment (P |
| Databáze: | OpenAIRE |
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