Polysaccharides isolated from liquid culture broth of Inonotus obliquus inhibit the invasion of human non-small cell lung carcinoma cells
| Autor: | Jun Myoung Park, Eock Kee Hong, Hee-Sun Yang, Joo-Hong Yeo, Byung Hyun Choi, Sarah Lee, Hye Jin Lee, Jong-Seok Lee, Ki Rim Lee |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cell Biomedical Engineering Bioengineering Biology Matrix metalloproteinase Polysaccharide Applied Microbiology and Biotechnology 03 medical and health sciences 0302 clinical medicine medicine Protein kinase B chemistry.chemical_classification A549 cell biology.organism_classification respiratory tract diseases 030104 developmental biology medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis Immunology Cancer research Phosphorylation Inonotus obliquus Signal transduction Biotechnology |
| Zdroj: | Biotechnology and Bioprocess Engineering. 22:45-51 |
| ISSN: | 1976-3816 1226-8372 |
| DOI: | 10.1007/s12257-016-0458-0 |
| Popis: | Polysaccharides isolated from Inonotus obliquus (PLIO) have been known to have various pharmacological activities including antioxidant, immunostimulating and anti-tumor activity. However, the anti-metastatic effect of PLIO in human non-small cell lung carcinoma (NSCLC) has not been elucidated. In this study, we investigated the effects of PLIO on the metastatic potential of human NSCLC A549 cells and its underlying mechanisms. PLIO suppressed the invasive potential of A549 cells throughout reducing matrix metalloproteinase (MMP) expression. PLIO treatment inhibited NF-κB nuclear translocation in A549 cells. In addition, PLIO treatment inhibited the phosphorylation of JNK/AKT in A549 cells. These results suggest that PLIO could inhibit human NSCLC invasion via suppression of AKT/NF-κB signaling pathway. |
| Databáze: | OpenAIRE |
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