High-frequency, vector-flow imaging in the left ventricle of FHF2 deficient murine heart
| Autor: | Akshay Shekhar, Orlando Aristizabal, Colin K L Phoon, Jeffrey A. Ketterling, Glenn I. Fishman |
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| Rok vydání: | 2020 |
| Předmět: |
Physics
Cardiac function curve Hemodynamics 030204 cardiovascular system & hematology medicine.disease Frequency vector Flow imaging Linear array 03 medical and health sciences 0302 clinical medicine Nuclear magnetic resonance medicine.anatomical_structure 030228 respiratory system Ventricle medicine Pericardium Brugada syndrome |
| Zdroj: | 2020 IEEE International Ultrasonics Symposium (IUS). |
| DOI: | 10.1109/ius46767.2020.9251834 |
| Popis: | The left ventricle (LV) of fibroblast growth factor homologous factor 2 (FHF2)-deficient (Fhf2KO/Y) and wild-type Fhf2WT/Y mice were imaged with high-speed, plane-wave methods using an 18-MHz linear array. Fhf2KO/Y present with hyperthermia-induced ECG abnormalities highly reminiscent of Brugada syndrome. Data were acquired at three transmission angles [-5, 0 5 degrees] at a rate of 30 kHz for a 1 sec duration while the core temperature of the mice were raised to 41.5° C. The data were processed to obtain vector-flow estimates, vorticity and pericardium motion at the far wall of the LV. The hemodynamics and pericardial-motion of the Fhf2WT/Y and Fhf2KO/Y mice were compared as a function of temperature. Above 40° C the Fhf2KO/Y mouse displayed disrupted flow patterns and greater beat-to-beat variation relative to the Fhf2WT/Y mouse. |
| Databáze: | OpenAIRE |
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