Dual-modality probe based on black phosphorous and NiFe2O4 NTs for electrochemiluminescence and photothermal detection of ovarian cancer marker
| Autor: | Yanyu Lin, Dandan Fang, Hong Dai, Defu Huang, Li Jianing |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
business.industry
Chemistry 010401 analytical chemistry Photothermal effect 02 engineering and technology Photothermal therapy Lipolysis stimulated lipoprotein receptor 021001 nanoscience & nanotechnology 01 natural sciences Signal 0104 chemical sciences Analytical Chemistry Quantum dot Electrochemiluminescence Optoelectronics Dual modality 0210 nano-technology business |
| Zdroj: | Talanta. 211:120660 |
| ISSN: | 0039-9140 |
| DOI: | 10.1016/j.talanta.2019.120660 |
| Popis: | An electrochemiluminescence and photothermal immunosensor based on a dual-modality integrated probe was proposed for sensitive and reliable detection of lipolysis stimulated lipoprotein receptor (LSR), a new biomarker of ovarian cancer. Black phosphorous quantum dots (BPQDs) possess fascinating electrochemical property and unique photothermal effect, which could not only enhance ECL signal of N-(4-aminobutyl)-N-ethylisoluminol (ABEI) through accelerating dissolved O2 evolution but also realize temperature signal output by converting laser energy into heat. Furthermore, NiFe2O4 nanotubes (NiFe2O4 NTs) have large specific surface area and favorable adsorption ability, which could increase the immobilized amount of ABEI and BPQDs, further strengthening ECL and temperature signal. As a result, a dual-mode immunosensor was constructed and realized ECL and temperature dual signal to detect LSR, making the results more reliable. This work provided a new thought for the development of sensitive and accurate sensors and was expected to employ for determination of other biomarkers. |
| Databáze: | OpenAIRE |
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