Recurrent Hepatitis C Virus (Genotype 4) Infection after Living Donor Liver Transplantation: Risk Factors and Outcome
| Autor: | Ayman Alsebaey, Emad H Salem, Amr Mostafa Aziz, T. Ibrahim, M. Taha, Khaled Abou El-Ella |
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| Rok vydání: | 2014 |
| Předmět: |
Hepatitis
medicine.medical_specialty Univariate analysis Cirrhosis medicine.diagnostic_test business.industry Liver dialysis medicine.medical_treatment virus diseases Liver transplantation medicine.disease Gastroenterology digestive system diseases Organ transplantation Surgery Hepatocellular carcinoma Internal medicine Liver biopsy medicine business |
| Zdroj: | Journal of Liver. |
| ISSN: | 2167-0889 |
| Popis: | Objectives: The recurrence of HCV post liver transplantation endangers patient and graft survival. The aim of this study is to analyze the risk factors for HCV recurrence, the effect of the recurrence and its management on the outcome of liver transplantation. Materials and methods: After exclusion of the 6 months mortality, dual HCV and HCC patients, about fifty five HCV related LDLT patients were enrolled in the study and were followed up from 6 to 60 months. Demographic, preoperative, intraoperative and postoperative data were studies. HCV recurrence was defined by elevated transaminases, positive serum HCV RNA and liver biopsy findings. Univariate and multivariate analysis were done on all data to detect the favoring factors of HCV recurrence. Results: HCV recurrence occurred in 21/55 of the patients and one of them developed cirrhosis on follow up. By univariate analysis; CMV infection, mean operative time (12.490 ± 1.8952), acute cellular rejection and pulse steroids treatment were predictors of HCV recurrence (P |
| Databáze: | OpenAIRE |
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