Harpalyce brasiliana Benth: A prolific source of bioactive flavonoids with antiophidic potential
| Autor: | Renata Mendonça Araújo, Nayara Coriolano de Aquino, Helena Serra Azul Monteiro, Ana Karoline Silva de Aquino, Edilberto R. Silveira, Manoela Torres-Rêgo, Yanna Carolina Ferreira Teles, Marcela de Castro Nogueira Diniz Pontes, Rafael Matos Ximenes |
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| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
biology Traditional medicine 010405 organic chemistry Chemistry Venom Plant Science biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Flavonols Alanine transaminase Phytochemical biology.protein Urea Bothrops Uric acid Hemoglobin Agronomy and Crop Science Biotechnology |
| Zdroj: | Phytochemistry Letters. 41:158-167 |
| ISSN: | 1874-3900 |
| Popis: | Harpalyce brasiliana Benth (Leguminoseae) has been previously described as a prolific source of flavonoids, such as flavonols, isoflavonoids and mainly pterocarpans. This plant has been used in folk medicine and its isolated compounds have been reported for their anti-inflammatory, antitumor and antiophidic properties. This study reports a phytochemical investigation of the leaves, heartwood, and roots of H. brasiliana and evaluates its effect against the Bothrops jararacussu (Bj) envenomation. The isolation of all substances was performed using different chromatographic methods and the structures were elucidated by 1D and 2D NMR, IR and MS analysis. The new isoflavonoids harpalycin II-A (4) and harpalycin I-A (9) were isolated from the leaves and heartwood, respectively. Thirteen known flavonoids were isolated from leaves, heartwood, and roots. The treatment of rats with cabenegrin A-II (14) reversed the biochemical (glucose, aspartate aminotransferase, alanine transaminase, urea, creatinine, uric acid, and creatine kinase) and hematological (erythrocytes, hemoglobin, hematocrit, hemoglobin and platelets) alterations induced by Bj venom. In addition, cabenegrin A-II demonstrated significant inhibition of the hypotensive effect of Bj venom. These data demonstrated the isolation of two new isoflavonoids of species, as well as the promising antiophidic effect of bioactive flavonoids from H. brasiliana. |
| Databáze: | OpenAIRE |
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