ChemInform Abstract: Synthesis of Substituted Pyridines from 1,2-Nucleophilic Addition Products of Functionalized N-Acyl-2,3-dihydropyridones

Autor:	Marcus W. Wright, Mustafa Guzel, Sezgin Kiren, Joshua Watts, Matthew McGilvary
Rok vydání:	2016
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Nucleophilic addition Chemistry Aryl Reagent Aromatization Chloranil General Medicine Combinatorial chemistry Alkyl
Zdroj:	ChemInform. 47
ISSN:	0931-7597
DOI:	10.1002/chin.201602136
Popis:	We describe herein a general and efficient synthetic approach toward substituted pyridines from functionalized N -acyl-2,3-dihydropyridones in two steps; 1,2-addition with organocerium reagents and subsequent oxidative aromatization with chloranil. This strategy allows the generation of pyridines with various substitution patterns and introduces a variety of substituents including aryl, alkyl, alkynyl, alkenyl, and heteroaryl groups at the desired positions.
Databáze:	OpenAIRE
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