| Autor: |
T. Sparwasser, G. B. Lipford |
| Rok vydání: |
2000 |
| Předmět: |
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| Zdroj: |
Immunobiology of Bacterial CpG-DNA ISBN: 9783642640773 |
| DOI: |
10.1007/978-3-642-59672-8_4 |
| Popis: |
Infectious pathogens that break through surface defences and reach underlying tissue or blood encounter an array of interior host defences. These fall basically into two classes: innate and adaptive defences. The innate system is the phylogenically older of the two branches and uses germline-encoded pattern-recognition receptors (PRR) to identify microbial invaders (Pugin et al. 1994). An example is CD14, a receptor for bacterial cell-wall components (CWCs), such as lipopolysaccharides (LPS) and lipoteichoic acids. CD14 recognises carbohydrate constituents commonly expressed on pathogens (Espevix et al. 1993; Zhang et al. 1994; Ulevitch and Tobias 1995; Cleveland et al. 1996) and signals “danger” to myeloid-lineage cells (Matzinger 1994). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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