Chemical constituents of the aerial parts of Salvia judaica Boiss. from Jordan
| Autor: | Hala I. Al-Jaber, Ethar F Khlaifat, Sahar O Ibrahim, Hasan Tashtoush, Musa H. Abu Zarga, Mahmoud A. Al-Qudah, Sultan T. Abu Orabi, Ayman M. Saleh |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Salvia judaica
biology 010405 organic chemistry Tormentic acid Rosmarinic acid Organic Chemistry Plant Science Ascorbic acid biology.organism_classification 01 natural sciences Biochemistry Cirsilineol 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Glucoside Apigenin Tricin Nuclear chemistry |
| Zdroj: | Natural Product Research. 34:2981-2985 |
| ISSN: | 1478-6427 1478-6419 |
| Popis: | Investigation of the chemical constituents of Salvia judaica growing wild in Jordan led to the isolation and identification of 15 known compounds. These included: luteolin-3'-methyl ether (1), indole-3-carboxyaldehyde (2), p-hydroxybenzaldehyde (3), tricin (4), apigenin (5), methyl isoferuloyl-7-(3,4-dihydroxyphenyl) lactate (6), methyl rosmarinate (7), rosmarinic acid (8), salvigenin (9), β-sitosterol (10), 3β, 28-dihydroxyurs-12-ene (11), cirsilineol (12), 2,3-dihydroxyurs-12-en-28-oic acid (13), β-sitosteryl glucoside (14), and tormentic acid (15). Compounds 6 and 7 exhibited strong radical scavenging and chelating activities as compared to α-tocopherol and ascorbic acid, compound 7 showed a 2-fold greater antioxidant activity as compared to compound 6. Furthermore, low doses of compounds 6 and 7 were able to inhibit the growth of leukemic (HL-60, Jurkat, K562 and CCRF-SB) and solid tumor cells (MCF-7, MDA-MB-231 and Caco-2). Compound 7 showed a ca. 3-4-fold stronger cytotoxicity against the tested cells as compared to compound 6. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|