| Autor: |
Yuichi Hirase, Takeshi Oguchi, Katsuyuki Iwatsuki, Akinori Sakai, Naoto Tsubokawa, Yasunori Hattori, Hideo Yasunaga, Takaaki Shinohara, Shiro Urata, Michiro Yamamoto, Tetsuro Onishi, Rikuo Shinomiya, Hitoshi Hirata, Katsuhiro Tokutake, Toshikazu Tanaka, Hiroyuki Kato, Etsuhiro Nakao, Hiroyuki Ohi, Masanori Hayashi, Shohei Omokawa, Norimasa Iwasaki, Tsuyoshi Tajika, Hiroyuki Gotani, Ryosuke Kakinoki, Kunitaka Menuki, Ataru Igarashi, Toshikazu Kurahashi, Toru Sunagawa, Kazuhiro Otani, Yuichiro Matsui, Hiroshi Koshima, Masahiro Tatebe, Yoshiaki Yamanaka, Rhoji Kajiwara, Nobuyuki Okui, Takanobu Nishizuka, Yoshio Kaji, Eiichi Nagayoshi, Akimasa Morita, Hiroaki Sakano, Hideo Hasegawa, Yoshitaka Tanaka, Kentaro Watanabe, Yuri Kanno, Katsumi Tanaka, Masao Nishiwaki, Hiroyasu Ikegami, Tetsu Katsumura |
| Rok vydání: |
2021 |
| Předmět: |
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| Popis: |
BackgroundThis study compared hand function and the cost effectiveness of treatment between collagenase Clostridium histolyticum (CCH) injection and limited fasciectomy for patients with Dupuytren’s contracture (DC).Materials and MethodsThe CeCORD-J study is a prospective, multicenter, non-randomized controlled, observational study of two parallel groups. Participants were DC patients with multiple affected fingers, including flexion contracture of the proximal interphalangeal (PIP) joint. The primary outcome was the Hand10 score, as a patient-reported outcome measure. We set secondary outcomes of EQ-5D-5L score, degree of extension deficit, and direct cost. Propensity score adjustment was used to balance differences in patient characteristics between groups.ResultsParticipants comprised 52 patients in the Collagenase group and 26 patients in the Surgery group. Hand10 score was significantly better in the Collagenase group at 1 and 2 weeks. EQ-5D-5L score was significantly higher in the Collagenase group at 8 weeks. Mean direct cost was 248,000 yen higher in the Surgery group than in the Collagenase group. Extension deficit angle of the PIP joint was significantly larger in the Collagenase group at 26 weeks.ConclusionsCCH injection provides better short-term hand function and cost effectiveness than surgery.UMIN-CTR (UMIN000029826) |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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