Alkaloids from the roots of Stemona tuberosa and their anti-tobacco mosaic virus activities

Autor:	Jie Guo, Xiao-Jiang Hao, Yu Zhang, Hong-Yu Tang, Zhan-Xing Hu, Haji Aker Aisa
Rok vydání:	2019
Předmět:	Stemona biology Mosaic virus 010405 organic chemistry Chemistry Stereochemistry Organic Chemistry 010402 general chemistry biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences Drug Discovery Tobacco mosaic virus Stemona tuberosa
Zdroj:	Tetrahedron. 75:1711-1716
ISSN:	0040-4020
DOI:	10.1016/j.tet.2018.11.064
Popis:	Stemtuberlines A (1) and B (2), two new alkaloids with a unique tricyclic pyrrolo [3,2,1-jk]benzazepine-12-one nucleus, three new croomine-type alkaloids, stemtuberlines C-E (3–5), together with seven known ones were isolated from the roots of Stemona tuberosa. The structures of the new alkaloids were elucidated based on a comprehensive spectroscopic data analysis. The absolute configurations of 1 and 2 were determined by quantum ECD calculations. The anti-tobacco mosaic virus activity of the Stemona alkaloids was firstly evaluated and compound 11 exhibited significant anti-tobacco mosaic virus activity with the curative inhibition rate of 84.6% at concentration of 50 μg/mL.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::98bcf40454e22e759a126f2e2757aa30 https://doi.org/10.1016/j.tet.2018.11.064 Zobrazit plný text záznamu Full Text from ScienceDirect