Multi-Criteria Decision Making to the Optimization of Reversed-Phase Liquid Chromatographic Separation of Six Anticonvulsant Agents in Serum: A Study with Potential for Use in Patient Drug Level Monitoring

Autor:	Pouneh Ebrahimi, H. Jafariyan, Soheila Honary, F Pourmorad
Rok vydání:	2010
Předmět:	Chromatography Multivariate analysis Chemistry Biochemistry (medical) Clinical Biochemistry Separation (statistics) Regression analysis Reversed-phase chromatography Biochemistry High-performance liquid chromatography Analytical Chemistry Chemometrics Anticonvulsant Agent Phase (matter) Electrochemistry Spectroscopy
Zdroj:	Analytical Letters. 43:240-250
ISSN:	1532-236X 0003-2719
DOI:	10.1080/00032710903325849
Popis:	The chemometrics approach was applied for the simultaneous optimization of separation quality and analysis time of six anticonvulsant agents in RP-HPLC. The effect of two experimental parameters was studied on retention by means of multivariate analysis. The factors considered were the organic modifier concentration and pH in the mobile phase. The experiments were performed according to a response surface experimental design. Then Pareto-Optimality method, an approach from multi-criteria decision making, was employed. The obtained regression models were characterized by both descriptive and predictive ability. After statistical evaluation, optimum conditions as well as quantitative values were shown and discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::988538e44172f26ca02382a5b2f1aca0 https://doi.org/10.1080/00032710903325849 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.