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The aim of this study was to investigate the rate of disappearance of noradrenaline in arterial grafts after their transplanation. Arterial grafts were harvested from AO/Ks:OC strain rats. In each rat, a graft was harvested from the femoral artery and transplanted into the common carotid artery. A contralateral unoperated femoral artery served as control. High-performance liquid chromatography (HPLC) with electrochemical detection was used to determine the noradrenaline content in grafts and controls. Immediately after grafting, the noradrenaline content was 76% of control value, at 6 h 130% of control value, and at 48 h 4% of control value. The drop in graft noradrenaline content (from 0-48 h) was statistically significant (P = 0.005). The difference between 0-h, 12-h, and 24-h groups was statistically insignificant. Compared to control specimens, grafts contained less noradrenaline after 12 h, and it disappeared almost completely from femoral arterial grafts in rats within 48 h. |
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