| Autor: |
Magnus Lundin, Einar Heiberg, David Nordlund, Tom Gyllenhammar, Katarina Steding-Ehrenborg, Henrik Engblom, Marcus Carlsson, Dan Atar, Jesper van der Pals, David Erlinge, Rasmus Borgquist, Ardavan Khoshnood, Ulf Ekelund, Jannike Nickander, Raquel Themudo, Sabrina Nordin, Rebecca Kozor, Anish N Bhuva, James C Moon, Eva Maret, Kenneth Caidahl, Andreas Sigfridsson, Peder Sörensson, Erik B Schelbert, Håkan Arheden, Martin Ugander |
| Rok vydání: |
2022 |
| DOI: |
10.1101/2022.10.16.22280561 |
| Popis: |
AIMSCardiovascular magnetic resonance (CMR) can accurately measure left ventricular (LV) mass, which is associated with morbidity and mortality. Several measures related to LV wall thickness exist, with uncertain relative prognostic strength. We hypothesized that prognosis can be used to select an optimal measure of wall thickness for characterizing LV hypertrophy.METHODS AND RESULTSSubjects having undergone CMR were studied (cardiac patients, n=2543; healthy volunteers, n=100). A new measure, global wall thickness (GT, GTI if indexed to body surface area), and related measures, including mass/volume and mass/volume2/3, were calculated. GT was accurately calculated from LV mass and LV end-diastolic volume. Among patients with follow-up (n=1575, median follow-up 5.4 years), the most predictive measure of death or hospitalization for heart failure was LV mass index (LVMI) (hazard ratio (HR)[95% confidence interval] 1.16[1.12–1.20], pCONCLUSIONSLV mass is highly prognostic when mass is elevated (advanced disease), but global wall thickness is easily and accurately calculated, and adds value and discrimination amongst those with normal mass (early disease). The combination of these two measures can be used to characterize hypertrophy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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