Chronische Granulozytopenie als Leitsymptom einer Tγ-Lymphozytose
| Autor: | G. Krieger, M. Kneba, G. A. Nagel, S. Gabius, G. Ohms |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
030203 arthritis & rheumatology
Recurrent infections Pathology medicine.medical_specialty Lymphocytosis business.industry General Medicine Differential blood count 3. Good health 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Antigen hemic and lymphatic diseases Immunohistochemistry Medicine Bone marrow Cortisone medicine.symptom Lymphoproliferative disease business 030215 immunology medicine.drug |
| Zdroj: | DMW - Deutsche Medizinische Wochenschrift. 114:1064-1068 |
| ISSN: | 1439-4413 0012-0472 |
| DOI: | 10.1055/s-2008-1066717 |
| Popis: | Routine examination of a 60-year-old woman with long-lasting rheumatic complaints revealed a granulocytopenia in the differential blood count (1% stab cells, 3% segmented) with a normal total leucocyte count (4,200/microliters). It was caused by a lymphoproliferative disease of the granular lymphocytes, which may also be termed T gamma lymphocytosis because of the predominant phenotype. As the lymphocytosis in blood and bone marrow was of minor degree, the diagnosis was confirmed only by immunocytochemical and molecular-genetic demonstration of clonal expansion of the T gamma lymphocytes. The granulocytopenia gradually became more marked and recurrent infections were noted. Treatment with cyclosporin and cortisone brought about remission of the granulocytopenia. |
| Databáze: | OpenAIRE |
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