Synthesis and biological evaluation of 4-deacetoxypaclitaxel

Autor:	Mahendra D. Chordia, David G. I. Kingston, Ernest Hamel, Y. Q. Jiang, Ashok G. Chaudhary
Rok vydání:	1994
Předmět:	biology Organic Chemistry Biological activity macromolecular substances Biochemistry In vitro chemistry.chemical_compound Tubulin Paclitaxel chemistry Cell culture Drug Discovery biology.protein Bioassay Diterpene Cytotoxicity
Zdroj:	Tetrahedron Letters. 35:6843-6846
ISSN:	0040-4039
DOI:	10.1016/0040-4039(94)85019-4
Popis:	4-Deacetoxypaclitaxel ( 9 ) has been prepared in seven steps from paclitaxel (Taxol ® ). It is significantly less active than paclitaxel in tubulin-assembly and cytotoxicity bioassays.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::97794edd8e3ae21290da674880a57c51 https://doi.org/10.1016/0040-4039(94)85019-4 Zobrazit plný text záznamu