Biotinylated-cationic zinc(II) phthalocyanine towards photodynamic therapy

Autor:	Saad Makhseed, Esra Nur Kaya, Basma Ghazal, Ali Husain, Asaithampi Ganesan, Mahmut Durmuş
Rok vydání:	2019
Předmět:	medicine.medical_treatment Cationic polymerization chemistry.chemical_element Photodynamic therapy General Chemistry Zinc Cancer treatment chemistry.chemical_compound chemistry Biotinylation Cancer cell Phthalocyanine medicine Cancer research Biotin receptors
Zdroj:	Journal of Porphyrins and Phthalocyanines. 23:46-55
ISSN:	1099-1409 1088-4246
DOI:	10.1142/s1088424618501158
Popis:	Targeting biotin receptors in cancer cells can improve specifying of photosensitizers (PSs) for cancer treatment by photodynamic therapy (PDT) applications. Consequently, there has been extensive research focusing mainly on the design of PSs with optimized pharmaceutical properties and better targeting toward cancer cells. Herein a tailored mono-biotinylated zinc(II) phthalocyanine (Pc-1) substituted with six phenoxy-bis(triazolyl) substituents has been synthesized. This Pc-1 has been further modified to its cationic version (Pc-2) through quaternizing of the triazole moiety to gain water solubility. Both non-ionic zinc(II) phthalocyanine (Pc-1) and its cationic derivative (Pc-2) were characterized by standard spectroscopic techniques, namely; FT-IR, 1H and [Formula: see text]C NMR, UV-Vis and MALDI-TOF, and by elemental analysis. The photophysical and photochemical properties were evaluated in DMSO for the non-ionic Pc-1 and in both DMSO and water for the cationic Pc-2.
Databáze:	OpenAIRE
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