Acteoside isolated from Colebrookea oppositifolia attenuates I/R brain injury in Wistar rats via modulation of HIF-1α, NF-κB, and VEGF pathways
| Autor: | Krishnadas Nandakumar, Gollapalle Lakshminarayanashastry Viswanatha, H. Shylaja, C H K V L S N Anjana Male, S. Rajesh |
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| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
medicine.medical_specialty Necrosis Antioxidant biology business.industry medicine.medical_treatment Immunology Histology NF-κB Glutathione Lipid peroxidation chemistry.chemical_compound Endocrinology chemistry Catalase Internal medicine Gene expression biology.protein Medicine Pharmacology (medical) medicine.symptom business |
| Zdroj: | Inflammopharmacology. 29:1565-1577 |
| ISSN: | 1568-5608 0925-4692 |
| DOI: | 10.1007/s10787-021-00851-6 |
| Popis: | The objective of this study was to assess the anti-stroke activity of acteoside isolated from methanolic root extract of C. oppositifolia Ischemia–reperfusion(I/R) brain injury was induced in Wistar rats to assess the anti-stroke activity of acteoside. Rats were pretreated with acteoside (10, 25 & 50 mg/kg, p.o.) before the induction of I/R injury. Parameters such as neurological, motor-cognitive functions were evaluated along with morphological (brain volume, infarct size), biochemical (SOD, Catalase, GSH, lipid peroxidation, TNF-α, IL-6, IL-10, ICAM-1, HIF-1α, VEGF, and NF-κB), histopathological, and gene expression studies (HIF-1α, VEGF) were performed to study the protective effect of acteoside against I/R induced brain injury. I/R injury caused significant deterioration of neurological (p |
| Databáze: | OpenAIRE |
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