Hypofractionated Radiation Therapy for Progressive Heterotopic Ossification: The Relationship between Dose and Efficacy
| Autor: | Young Woo Kim, In Yong Whang, Hang Joo Cho, Maru Kim, Dong Soo Lee |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Cancer Research
Radiation Hypofractionated Radiation Therapy business.industry Ossification medicine.medical_treatment Treatment outcome medicine.disease 030218 nuclear medicine & medical imaging Radiation therapy 03 medical and health sciences Dose–response relationship 0302 clinical medicine Oncology 030220 oncology & carcinogenesis Toxicity medicine Radiology Nuclear Medicine and imaging Heterotopic ossification Femur medicine.symptom business Nuclear medicine |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 106:993-997 |
| ISSN: | 0360-3016 |
| Popis: | Purpose We sought to evaluate treatment outcomes after hypofractionated short-course radiation therapy (RT) for progressive heterotopic ossification (HO). Methods and Materials Nine consecutive patients were treated between January 2016 and December 2018. None had received previous preventive RT. RT was performed to prevent further HO progression with one of the following dose-fractionation regimens: 7 Gy × 2 fractions, 9 Gy × 1 fraction, 6 Gy × 2 fractions, 6 Gy × 3 fractions, 8 Gy × 2 fractions, or 7 Gy × 3 fractions. Results All patients were male, with a median age of 30 years (range, 16-55). Eight patients presented with grade III Brooker classification. The most commonly involved site was the hip, followed by femur and knee. With a median assessment time of 7.1 (range, 5.1-23.1) months, eight patients achieved decreased HO, with five showing a dramatic (≥50%) reduction. Among the five excellent responders, a 21 Gy with 7 Gy per fraction schedule was used in four patients. HO status was maintained at the final median follow-up of 11.6 months (range, 6.2-36.1), and Brooker’s grade was improved in three patients. No significant RT-related toxicity was noted. Conclusions The current RT scheme was effective for the management of progressive HO. It is speculated that higher RT doses could result in the superior efficacy of progressive HO. |
| Databáze: | OpenAIRE |
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