Endothelial Dysfunction and Phenylephrine-Induced Hypocontractility Occurs in Mesenteric Resistance Arteries Prior to the Onset of Alzheimer's Disease in Mice
| Autor: | Emily W. Waigi, Laena Pernomian, Paul Townsend, Emily W. Wilson, R. Clinton Webb, Cameron G. McCarthy, Camilla F. Wenceslau |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Physiology. 38 |
| ISSN: | 1548-9221 1548-9213 |
| DOI: | 10.1152/physiol.2023.38.s1.5731729 |
| Popis: | Alzheimer’s Disease (AD) is the most common form of dementia and a major cause of disability and death among the older population. In addition, Cardiovascular dieseases (CVDs) and their risk factors are associated with an increased risk of the progression of AD and cognitive impairment. Despite this, studying the combination of these diseases constitutes a clinical challenge, and investigations to understand the mechanistic pathways for the cause-effect and/or shared pathology between them remains an active area of research. One form of AD, familial AD, is linked with an early onset AD (EOAD) pathology ( R00GM118885, R01HL149762, R00HL151889, and NHLBI (R00HL151889) This is the full abstract presented at the American Physiology Summit 2023 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process. |
| Databáze: | OpenAIRE |
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