| Autor: |
Tsun-Yung Kuo, Chia En Lien, Yi-Jiun Lin, Meei-Yun Lin, Luke Tzu-Chi Liu, Chung-Chin Wu, Wei-Hsuan Tang, Charles Chen |
| Rok vydání: |
2022 |
| DOI: |
10.1101/2022.10.07.511263 |
| Popis: |
The dominance of SARS-CoV-2 variants of concern (VoC), such as the Omicron subvariants, is a threat to the current vaccination scheme due to increased resistance to immune neutralization and greater transmissibility. To develop the next generation of prefusion SARS-CoV-2 spike protein (S-2P) subunit vaccine adjuvanted with CpG1018 and aluminum hydroxide, mice immunized with two doses of the adjuvanted ancestral Wuhan strain (W) followed by the third dose of the W or Omicron variants (BA.1 or BA.4/BA.5) S-2P, or a combination of the above bivalent S-2Ps. Antisera from mice were tested against pseudovirus neutralization assay of ancestral SARS-CoV-2 (WT) and Omicron BA.4/BA.5 subvariant. Boosting with bivalent mixture of Omicron BA.4/BA.5 and W S-2P achieved the highest neutralizing antibody titers against BA.4/BA.5 subvariant pseudovirus compared to other types of S-2P as boosters. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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