Flavonoids from the Leaves of Bridelia stipularis with in Vitro Antioxidant and Cytotoxicity Activity
| Autor: | Kazi Ruhullah Shahriar, Choudhury M. Hasan, Monira Ahsan, Sangita Debnath Puja |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Antioxidant biology Bridelia stipularis Traditional medicine 010405 organic chemistry medicine.medical_treatment Flavonoid Ethyl acetate Brine shrimp biology.organism_classification 01 natural sciences 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Apigenin medicine Petroleum ether Luteolin |
| Zdroj: | Pharmacology & Pharmacy. 11:137-146 |
| ISSN: | 2157-9431 2157-9423 |
| Popis: | Methanolic extract of the leaves of Bridelia stipularis was studied. From this study, we isolated three known flavonoids. They were identified as 7-O-methyl luteolin, apigenin and 5, 7, 2’, 5’ tetrahydroxyflavone by NMR spectroscopic studies. All of them are first time documented for this plant. Different solvent fractions were subjected to in vitro antioxidant and cytotoxicity studies. Both apigenin and ethyl acetate soluble fraction of Bridelia stipularis showed strong antioxidant activity having IC50 value of 8.005, 8.77 μg/mL respectively. Chloroform soluble fraction of Bridelia stipularis exerted the highest toxicity to brine shrimp and petroleum ether soluble fraction showed moderate toxicity having LC50 value of 1.05, 1.71 μg/mL respectively. |
| Databáze: | OpenAIRE |
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