Efficient esterification of curcumin in bis(trifluoromethylsulfonyl)imide-based ionic liquids
| Autor: | Marcin Gano, Joanna Klebeko, Robert Pełech |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Kinetics
02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences Atomic and Molecular Physics and Optics 0104 chemical sciences Electronic Optical and Magnetic Materials Reaction rate chemistry.chemical_compound chemistry Ionic liquid Materials Chemistry Curcumin Organic chemistry Ammonium Pyridinium Physical and Theoretical Chemistry Chemical equilibrium 0210 nano-technology Imide Spectroscopy |
| Zdroj: | Journal of Molecular Liquids. 337:116420 |
| ISSN: | 0167-7322 |
| DOI: | 10.1016/j.molliq.2021.116420 |
| Popis: | In this paper, the potential application of bis(trifluoromethylsulfonyl)imide based ionic liquids paired with various cations (ammonium, piperidinium, pyridinium and imidazolium) as the recyclable reaction media for the esterification of curcumin has been investigated. The results showed that it is possible to obtain the product of curcumin diacetate (DAC) at moderate conditions and exclude the use of organic solvents, which is a high improvement in comparison to the known methods for prodrugs intermediates synthesis. In addition, the mechanism and kinetics of the esterification reaction have been studied. The presence of IL allows to reach the chemical equilibrium more rapidly, they also increase the reaction rate of the process. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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